Documentation Index
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Birch-type reductive alkylation, named after Arthur Birch, uses alkali metals (Na or Li) in liquid ammonia to produce a reducing agent that typically acts alongside a proton source (usually alcohol) to selectively reduce enones to lithium enolates.1 2 3 4 5 These enolates can undergo regioselective C-alkylation with alkyl halides, enabling controlled functionalization of unsymmetrical ketones. 1 2 3 4 5